when can we definitely know that sequences capture the properties of the topological space? --- See the Wikipedia article sequential space. Also, a wider class of topological spaces, but not ALL topological spaces, can be characterized if we replace ordinary sequences with arbitrary transfinite ordinal sequences --- see is a net stronger than a transfinite sequence for characterizing topology? AND Intuition behind nets. The use of transfinite ordinal sequences is a natural way to overcome the lack of first countability, but it turns out that more than just higher-cardinality "countability conditions" are needed to capture the notion of a point being in the closure of a set. That is, for topological spaces in general, being able to capture the notion of a point being in the closure of a set takes more than just having "long enough sequences to reach the point".
To summarize, every first countable space is a sequential space. However, there are sequential spaces that are not first countable spaces. For the analogs in the case of transfinite ordinal sequences (i.e. when you use ordinals to obtain longer "sequences" than is possible using ordinary indexed-by-natural-numbers sequences), the relevant terms are local character (or character at a point), which generalizes first countability to higher cardinalities, and radial space, which generalizes sequential spaces to various ways one can deal with sequences of transfinite lengths.