The background of this question is this: Fermat proved that the equation, $$x^4+y^4 = z^2\qquad$$
has no solution in the positive integers. If we consider the near-miss, $$x^4+y^4 = z^2 + 1$$
then this has plenty. (In fact, an infinity, as it can be solved by a Pell equation.) But for,
$$x^4+y^4 = z^2 - 1$$
in 2011, J. Cullen found this has none with $0 < x<y < 10^6$ while in 2012, Joro in this MO answer found none with $0<y<7.9\cdot10^7$.
Q: Does the third equation really have no solutions at all, or are they just enormous?
Update (2025):
Do we now have the computing power to check higher? To compare, in 1966, Lander, Parkin, and Selfridge searched,
$$a^4+b^4+c^4 = d^4$$
but stopped at $d<220000$. If they only doubled the search range, they would have found the smallest,
$$95800^4 + 217519^4 + 414560^4 = 422481^4$$
later found by Roger Frye in 1988, so was a missed opportunity. In 2024, Zhongqi Zhou claimed the equation in the title has no integer solution $xyz\neq0$. But as the paper in Section 3 also states, "...it follows that there are infinitely many twin primes", then I have my doubts.