The best way to approach this would be to use a global (config) container.
In most cases you will have a config file in your application. In this config you can add a property which will be an object containing all absolute paths to files/folders.
Because config files are used at the start of you application, you just do the following:
var config = require("./config.js");
//config = {... , path: {"someModule": "/absolute/path/to", "someModule2": "/absolute/path/to"...}}
global.CONFIG_CONTAINER = config
Later on in your application you can just use
var myModule = require(CONFIG_CONTAINER.path.someModule)
// + concat if you are looking for a file
In case you have some complex paths and you need a more dynamic system, you can always implement a function inside the config that will build paths for you. ( config.makePath = function(){...} )
That should take care of it in a nutshell.