Given an infinitely-presented group $G$, can I get a smooth manifold $M$ whose fundamental group $\pi_1(M)\cong G$?
This is true if $G$ is finitely-presented and $n\geq 4$, for $n=3$ this post gives some hints on why it is false.
I know there are some restrictions, for given a compact connected smooth manifold, it admits a Riemannian metric such that pulling it back via the universal covering, its fundamental group acts geometrically. In particular, we can prove that $\pi_1(G)$ is finitely-presented.