The general answer to question 1 is 'no', but a slight modification of the hypotheses makes it a 'yes'. This modified question and answer sheds some light on the original question.
Modified question: Let $A,B \subset G$ be normal, and suppose there is a homomorphism $G \to B$ with kernel $A$ and whose restriction to $B$ is an isomorphism. Then is there a corresponding map $G \to A$ with kernel $B$?
Answer: yes, and in fact $G \cong A \times B$.
Proof sketch: Since the restriction of $f$ to $B$ is an isomorphism, and $ker(f)=A$, the two subgroups $A$ and $B$ are disjoint and generate $G$. Then for all $a\in A$, $b \in B$, we know that $$aba^{-1}b^{-1} = (aba^{-1})b^{-1} = a(ba^{-1}b^{-1})$$ is in both $A$ and $B$, since they are normal. Then $aba^{-1}b^{-1}$ is trivial and hence all elements of $A$ and $B$ commute. Since $A$ and $B$ together generate $G$, we conclude $G \cong A \times B$.
Alternate, (harder) but more enlightening proof sketch: The map $f$ splits, so $G$ decomposes as a semidirect product $G = A \rtimes B$ (see here). Since $B$ is normal, the action of $B$ on $A$ must be trivial. A semidirect product with a trivial action is just a direct product.
The upshot is that the condition $G/A \cong B$ occasionally allows us to decompose the ambient group into pieces related to $A$ and $B$. The most powerful way to make this happen is the "splitting criterion" which is essentially the condition I added earlier.
In order to find a counterexample to the original statement, we need to look for $A,B \subset G$ so that $G/A\cong B$, but the quotient map is not an isomorphism when restricted to $B$. In the jargon of group extensions, we are searching for a non-split extension. We also have the additional requirement that $A$ and $B$ be normal. The klein-bottle group $$G = \langle a,b \mid bab^{-1} = a^{-1}\rangle$$ works: one can check that $A = \langle a\rangle$ and $B = \langle b^2\rangle \cong \mathbb{Z}$ are normal, and that $G/A \cong \mathbb{Z} \cong B$, but the image of $B$ under the quotient map is $2\mathbb{Z} \subset \mathbb{Z}$. However, $G/B \cong D_\infty\not \cong A$, so this works as a counterexample.