I'm studying inequalities involving positive definite symmetric matrices and their principal submatrices. Let $M$ be a positive definite symmetric matrix, partitioned as follows: $$ M = \begin{pmatrix} M_{11} & M_{12} \\ M_{21} & M_{22} \end{pmatrix} $$ where $M_{11}$ is the leading principal submatrix of $M$, and $M_{12} = M_{21}'$ represent the off-diagonal blocks. As $M$ is positive definite we know that $x'Mx > 0$ for all non-zero vectors $x$. Moreover, let's write $x = (x_1, x_2)$, then we also know that $x_1' M_{11}x_1 > 0$ and $x_2'M_{22}x_2 > 0$ for all non-zero vectors $x_1$ and $x_2$ of appropriate length (see this post).
Specifically, I’m interested in understanding when the inequality $c \cdot x_1' M_{11} x_1 \leq x' M x $ might hold for some constant $c > 0$.
Clearly, when the off-diagonals blocks are zero, this inequality holds for $c = 1$. However, when these are non-zero, this does not hold for $c = 1$. Here’s an example that demonstrates this.
Define $M$ as $$ M = \begin{pmatrix} 5 & 2 \\ 2 & 1 \end{pmatrix}, $$ and let $x = \begin{pmatrix} 2 \\ -1 \end{pmatrix}$. Then, $$ x' M x = \begin{pmatrix} 2 & -1 \end{pmatrix} \begin{pmatrix} 5 & 2 \\ 2 & 1 \end{pmatrix} \begin{pmatrix} 2 \\ -1 \end{pmatrix} = 13. $$
Now consider the leading principal submatrix $M_{11} = \begin{pmatrix} 5 \end{pmatrix}$ and vector $x_1 = \begin{pmatrix} 2 \\ 0 \end{pmatrix}$: $$ x_1' M_{11} x_1 = 2 \cdot 5 \cdot 2 = 20. $$
In this case, we find that $x' M x = 13$ while $x_1' M_{11} x_1 = 20$, so the inequality $x' M x \geq x_1' M_{11} x_1$ does not hold.
So my question is: For positive definite symmetric matrices $M$, does there exist a constant $c > 0$ such that the inequality $c \cdot x_1' M_{11} x_1 \leq x' M x$ always holds?
Any insights or references on this question would be highly appreciated!