I had this question because I had to prove for a problem that $2^n+1 \not \mid (n-1)!$, so I thought it would be nice for there to be a prime factor of $2^n+1$ that is greater than $n-1$. I checked this using code and it's true up to $n=89$, but $2^n$ grows pretty fast. I also tried using assuming all prime divisors $p$ of $2^n+1$ are less than $n$ for contradiction, but I couldn't get anything from it aside from the fact that if $2^n+1$ is semiprime then it has a prime factor that is greater than $n$. However there exist some of these numbers that aren't at most semiprime ($2^9+1=513=3^3\cdot19$).
Is there something very simple I'm missing? Is there a really big counterexample I don't know about?