This is the exercise 2.5.5 in the book 'Complex Geometry' by Huybrechts:
Let $X$ be a K3 surface, i.e. $X$ is a compact complex surface with $K_X\cong\mathscr{O}_X$ and $h^1(X,\mathscr{O}_X)=0$. Show that $X$ is not the blow-up of any other smooth surface.
Here $\dim X=2$, so if $X=\mathrm{Bl}_{\ell}S$ where $\dim\ell=1$ in $S$, then $X=S$. So we just need to consider the case $X=\mathrm{Bl}_{x}S$ where $x$ is a point of $S$. In this case $X=\mathrm{Bl}_{x}S\cong S\#\bar{\mathbb{P}^2}$. Now we have $\mathscr{O}_X=K_X\cong\sigma^*K_S\otimes\mathscr{O}_X(E)$ where $E$ is the exceptional divisor of the blow-up $\sigma:X\to S$. I tried to show that $\sigma^*K_S\otimes\mathscr{O}_X(E)$ must has a non-trivial global section, but I can't. Moreover, I don't know how to use $h^1(X,\mathscr{O}_X)=0$.
Actually, I guess in this case $h^1(X,\mathscr{O}_X)$ means $H^1(X,\mathscr{O}_X)$ since in this book $h^1(X,\mathscr{O}_X)=\dim H^1(X,\mathscr{O}_X)$.
Thank you for your help!