I built Pascal's triangle in a spreadsheet program, but always reducing mod 2000. There's never a need to keep more than the result mod $2000$. The result I get is $1620$.
- Cell A2:
0
- Cell A3:
=A2+1 and carry down to Cell A82 with value $80$.
- Cell B1:
0
- Cell C1:
=B1+1 and carry rightward to Cell AP1 with value $40$.
Now these are the indices of Pascal's triangle. For $\binom{n}{k}$, $n$ is in column A and $k$ is in row 1.
- Cell B2:
1 and carry all the way down.
- Cell C3:
=MOD(B2+C2,2000), carry all the way rightward, and then all the way down, filling out the table.
Now Cell AP82 is $\binom{80}{40}$ mod $2000$. It gives $1620$.
To do this by hand, at first it may seem like you would calculate about $80\cdot40=3200$ cell entries mod $2000$. But actually you would only need to compute about $\frac14$ of those entries, as represented in blue here:

The red is all $0$. The orange is not needed to reach the $\binom{80}{40}$ cell. And the green can be written using symmetry from the blue. So this would take about $800$ additions mod $2000$ plus some other less signiicant labor.
But we an do better, because there is the identity $$\binom{80}{40}=\sum_{n=0}^{40}\binom{40}{n}^2=\binom{40}{20}+2\sum_{n=0}^{19}\binom{40}{n}^2$$
So actually if we can get Pascal's triangle down to the first half of the 40th row, then we can square mod $2000$ about 20 times, double, sum the results mod $20$ and have our answer.
A similar analysis reveals that you would need to calculate about $400$ of the entries of Pascal's triangle mod $2000$ for this approach.