This question is related to the answer of "Category theory from the first order logic point of view". They says:
Any model of this theory is a category. Unfortunately, however, that would beg the question of what to use as a model-construction language. First-order logic is typically associated with models constructed in a set theory such as ZF. That would defeat the whole purpose of this as an alternative foundation, as well as limiting us to "small" or "internal" categories.
I don't know fully what this mean. As described in this answer, axioms of category theory is formulated by first order logic and so it will seems that we can even treat models of axioms of category theory. One reason I think is ZF contradict the existence of a model such as $Set$(i.e the category of sets). Therefore I think if we assume ZFC+the existence of Grothendieck Universe then we don't need "small" or "internal" categories.Is it correct?