I know that S(5) is not cyclic.
If $S(5) = (1 2 3 4 5)$, you could say $(1 2 3 4 5) = (2 3)(3 4)(4 5)(1 5) = (1 5)(1 4)(1 3)(1 2)$, giving us various sets of four 2-cycles.
Is 4 the smallest number of elements needed to generate S(5)? Is there a different way to generate $S(5)$ using a smaller number of elements?