In algebraic geometry, the importance of non-trivial Grothendieck topologies is very well-known. One starts out with the Zariski topology on $\mathsf{Sch}$, but concludes that it is 'too coarse' for cohomological techniques to work, and so one develops the more refined étale topology as a remedy. The validity of étale descent is central to why the topology works in the first place. Ever since then, one often finds algebraic geometers playing with the various topologies, sometimes even developing new ones that get as close as possible to their needs.
Contrast this to 'ordinary' topology, where one has the archetypical Grothendieck topology on $\mathsf{Top}$ in which coverings are simply declared to be the open coverings in the classical sense. I do not recall having ever seen any other Grothendieck topology, and certainly no interesting ones. One could declare coverings to be jointly surjective, but that topology would fail to be subcanonical. What about covering spaces? Perhaps we may declare coverings to be one-element sets $\{Y \to X\}$ in which the map $Y \to X$ is a covering space.
Do you know of any interesting Grothendieck topologies on $\mathsf{Top}$? Are they as varied as they are on $\mathsf{Sch}$, and are there any applications to their existence?