I apologize in advance for the vagueness of this question.
It is known that there exist differential manifolds that are homeomorphic but not diffeomorphic to spheres (Milnor), and likewise there are manifolds homeomorphic but not diffeomorphic to $\mathbb R^4$ (due to Donaldson I think).
I'm having a hard time developing a mental picture of these objects. Does anyone have a good idea of how to think (more or less intuitively) about such spaces?