Consider $p(x,y,z):=x^2-yz$ as a polynomial in $R[x]$, where $R:=F[y,z]$ is a unique factorization domain. If we can show that $p(x,y,z)$ is irreducible in $R[x]=F[x,y,z]$, then we are done. First, note that $y$ is a prime element of $R$. The constant term of $p(x,y,z)$ as a polynomial in $x$ is $-yz$ which is not in the ideal generated by $y^2$ of $R$. The coefficient of $x$ in $p(x,y,z)$ is $0$, which belongs in the ideal generated by $y$ of $R$. Using Eisenstein's Criterion for integral domains, we conclude that $p(x,y,z)$ is irreducible in $R[x]=F[x,y,z]$. Since $F[x,y,z]$ is a unique factorization domain, $p(x,y,z)=x^2-yz$ is a prime element. That is,
$$F[x,y,z]/\langle x^2-yz\rangle$$
is an integral domain.