Take any $2 \times 2$ matrix $A$. Then $A$ is defind to be positive definite if for any $v\in \mathbb R^2$ except the zero vector, it is the case that $v^TAv>0$
This expression 'simplifies' to $$\forall x,y\in \mathbb R: ax^2+(b+c)xy+dy^2>0$$ where $a, b, c, d$ are the elements of $A$.
if we take first $x=0$, and then $y=0$, then we find that it must hold that $$a>0$$ $$d>0$$ i.e. the diagonal elements of $A$ must be positive.
Now if we define $k\in \mathbb R$ so that $x=-ky$, then our condition becomes: $$\forall k>0: ak^2-(b+c)k+d>0$$
I can find a number of restrictions on the parameters, simply by choosing for example $k=1, k=2$:
$$a+d>b+c$$ $$4a+d>2(b+c)$$
But I don't know how to turn this into a finite set of simple constraints on the parameters that are necessary and sufficient.