I'd like to answer this question without using a calculator.
My first instinct is to find a pattern in the value of $2^k$:
$2^1 \equiv 2$, $2^2 \equiv 4$, $2^3 \equiv 8$, $2^4 \equiv 6$, $2^5 \equiv 2,...$
So units digit repeat with period $4$ digits: $2,4,8,6,2,4,8,6...$
Now I'm stuck, how do I know which digit to pick from the set above