The Wikipedia page for the Binomial Distribution states the following lower bound, which I suppose can also be generalized as a general Chernoff lower bound.
$$\Pr(X \le k) \geq \frac{1}{(n+1)^2} \exp\left(-nD\left(\frac{k}{n}\left|\right|p\right)\right) \quad\quad\mbox{if }p<\frac{k}{n}<1$$
Clearly this is tight up to the $(n+1)^{-2}$ factor.
However computationally it seems that $(n+1)^{-1}$ would be tight as well. Even (n+1)^{-.7} seems to be fine.
It's not as easy to find lower bounds for tails as it is upper, but for the Normal Distribution there seems to be a standard bound:
$$\int_x^\infty e^{-t^2/2}dt \ge (1/x-1/x^3)e^{-x^2/2}$$
My question is thus, is the $\frac{1}{(n+1)^2}$ factor the best known? Or can $\frac{1}{n+1}$ be shown to be sufficient?
Update: Here is the region in which the conjecture holds numerically, by Mathematica:
