When comparing Speck to Threefish's Mix:
The difference is that Threefish uses multiple rotation constants and only a single word is rotated in contrast to Speck which uses the same rotations every round and rotates both words in different directions.
Why do the two approaches differ? And is one measurably better?
One thing I noted is that when both words are rotated in different directions it is not that different from rotating a single word more, there is however a difference in the result of modulo64 addition - does that somehow help enough to justify an extra operation?

