One way to answer this question would be to consider how many 4 letter words contain a certain number of A's.
For words containing 3 A's, there are two choices for the final letter, and 4 different reorderings, so 8 such words.
For words containing 2 A's , we can take the final two letters as 4 ordered choices, and then there are 6 ways of reordering the A's, so 24 such possibilities.
For words containing 1 A, there are 8 ordered choices for the final three letters, and 4 different choices for the position of A. So 32 choices.
And for words containing 0 A's , there are 16 ordered choices for the final four letters.
So overall, 8+24+32+16=80 words
A much nicer way to see this is that you can make all the words you would be able to make without the restriction apart from AAAA , so if you could use every letter as many times as you would like, then there would be 3^4=81 possible ways to form words. As you can't use AAAA, take away one , and you get 80.