As tomasz says in the comments, "transfinite construction" here just means a construction by transfinite recursion. And the idea is to construct the differential closure by repeatedly (transfinitely) applying Lemma 4.7.6.
Let me spell out some details for you. Let $K$ be a differential field.
- Let's define a differential problem in $K$ to be a pair $(P,Q)$, where for some $r$, $P\in K[Y,\dots,Y^{(r)}]$, $Q\in K[Y,\dots,Y^{(r-1)}]$, both are non-zero, and $Y^{(r)}$ occurs in $P$.
- A solution to this problem is an element $y\in K$ such that $P(y) = 0$ and $Q(y)\neq 0$.
- Then $K$ is differentially closed if every differential problem in $K$ has a solution in $K$.
- Let's say that a differential field extension $K'$ of $K$ is small over $K$ (my terminology) if every embedding of $K$ into a differentially closed field extends to an embedding of $K'$.
- Lemma 4.7.6 says that every differential problem in a differential field $K$ has a solution in a differential field extension $K'$ which is small over $K$.
- Finally, a differential closure of $K$ is a differentially closed differential field extension of $K$ which is small over $K$.
Let's construct a differential closure of $K$. Enumerate the differential problems in $K$ as $(P_\alpha,Q_\alpha)_{\alpha<\kappa}$ for some cardinal $\kappa$. We build a chain $(K_\alpha)_{\alpha\leq\kappa}$ of differential field extensions of $K$.
Base case: $K_0 = K$.
Limit step: For $\alpha$ a limit ordinal, define $K_\alpha$ to be the union (directed colimit) of the chain $(K_\beta)_{\beta<\alpha}$.
Successor step: Apply Lemma 4.7.6 to find a differential field extension $K_{\alpha+1}$ which is small over $K_\alpha$ and contains a solution to the differential problem $(P_\alpha,Q_\alpha)$.
Now $K_\kappa$ is a differential field extension of $K$ which is small over $K$ (prove smallness by a straightforward transfinite induction) and contains solutions to all differential problems in $K$ (by construction, $(P_\alpha,Q_\alpha)$ has a solution in $K_{\alpha+1}$ and hence in $K_\kappa$). But $K_\kappa$ may not be differentially closed, since there are new differential problems in $K_\kappa$ that weren't in $K$.
To solve this, define $K^0 = K$ and $K^1 = K_\kappa$, and for each $K^i$, repeat the construction above to find $K^{i+1}$ which is small over $K$ and contains solutions to all differential problems in $K^{i}$. Let $K^\omega$ be the union (directed colimit) of $(K^{i})_{i\in \omega}$. Then $K^\omega$ is a differential closure of $K$, since every differential problem in $K^\omega$ is already in $K^i$ for some $i$ and hence has a solution in $K^{i+1}$, and hence in $K^\omega$.