One of the disadvantages that occurs by simply augmenting a formal symbol indicating infinitesimal quantity and infinitely large quantity is that many algebraic properties no longer hold. We expect that this augmentation results in a systematic way of dealing limits in a more intuitive way, and the breakdown of algebra is certainly not what we wanted in this blueprint.
And even if we succeed in enlarging $\Bbb{R}$ by adding such objects in some way that raises no algebraic issue somehow, it is very hard to relate the calculus on the resulting number system, say $F$, to the usual calculus on $\Bbb{R}$. For example, you may want to prove the continuity of $\sin x$ by arguing that
Assume $\epsilon \approx 0$. Then $\sin \epsilon \approx 0$ and $\cos \epsilon \approx 1$. Now, by the addition formula $$\sin (x + \epsilon) = \sin x \cos \epsilon + \cos x \sin \epsilon,$$ we have $\sin (x+\epsilon) \approx \sin x$.
This seemingly appealing argument, however, required us to define a sine function on $F$ which is consistent with the original one on $\Bbb{R}$. And as you may realize, this is quite a non-trivial job. Indeed, even the power series defining $\sin x$ is not guaranteed to converge in $F$ for $x = \epsilon$ as $F$ is not complete!
Historically, avoiding this catastrophe while achieving a sufficiently intuitive and powerful way of dealing with limits as infinitesimal calculus had been considered very hard until Abraham Robinson came up with his famous hyperreal number system. This number system is an ordered field $\Bbb{R}^{*}$ containing the real field $\Bbb{R}$ as a proper subset such that
- $\Bbb{R}^{*}$ contains both infinitesimally small numbers and infinitely large numbers, whose notions are intuitively well-behaving under the arithmetic operations and order relation.
- The transfer principle holds: For any reasonably simple statement on $\Bbb{R}$, its hyperreal version is true if and only if its original version is true.
Since any non-Archimedean ordered field that extends $\Bbb{R}$ satisfies the property 1 in some sense, it is the transfer principle that makes the notion of hyperreal numbers a powerful tool for infinitesimal calculus.