If $F: \mathcal{C} \to \mathcal{D}$ is full, then the image of $F$ is always a category. Clearly we have identity arrows on each object, and composition will be associative since it is associative in $\mathcal{D}$. So we only need to check that the image of $F$ is closed under composition (see also this answer to see what could go wrong).
Let $F(f): F(A) \to F(B)$ and $F(g): F(C) \to F(D)$ be arrows in the image of $F$, such that $F(B) = F(C)$. Then we can compose $F(f)$ and $F(g)$ in $\mathcal{D}$ to get $F(g)F(f): F(A) \to F(D)$. Since $F$ is full, we find $h: A \to D$ such that $F(h) = F(g)F(f)$. So $F(g)F(f)$ is in the image of $F$, and so the image of $F$ is closed under composition.
It may also be worth pointing out that if $F$ is injective on objects, its image forms a category. Again you need to check that it's closed under composition, which is an easy exercise.