This is to complement user2097's answer.
Lemma: Let $F=\mathbb{F}_2(y,z)$ and $g(t)=t^2+yt+z\in F[t]$. Then
- $g(t)$ is an irreducible separable polynomial over $F$, let $\alpha$ be a root of $g$ in an algebraic closure of $F$, so $F(\alpha)/F$ is separable of degree 2.
- $f(t):=g(t^2)=t^4+yt^2+z$ is irreducible over $F$ of degree 4 with a root $x=\alpha^{1/2}$, so $F(\alpha^{1/2})/F$ is of degree 4 and $F(\alpha^{1/2})/F(\alpha)$ is purely inseparable of degree 2. Let $E=F(\alpha^{1/2})$, then the separable closure $E^s$ of $F$ in $E$ is $E^s=F(\alpha)$.
- Let $K$ be the set of all elements of $E$ that are purely inseparable over $F$, then $K=F$ and thus $E/K$ is not purely inseparable.
Proof. (1) As $\deg g>0$, the irreducibility of $g$ can be checked over $\mathbb{F}_2[y,z]$. Quotient out the prime ideal $(y)$, we have $\overline{g}(t)=t^2+z\in \mathbb{F}_2[z][t]$ which is irreducible by Eisenstein's Criterion with the prime ideal chosen to be $(z)$. So $g$ is irreducible over $F$. An irreducible polynomial over a field is separable iff its formal derivative is non-zero. Plus that $g^\prime(t)=y\neq 0$, so $g$ is separable.
It follows that $F(\alpha)/F$ is separable of degree 2.
(2) Here we use a lemma [Let $F$ be a field of characteristic $p>0$ and $f(x)$ be an irreducible polynomial over $F$, if one of the coefficients of $f$ is not in $F^p$, then $f(x^q)$ is irreducible for all $p$-power $q=p^r$ with $r\geq 0$. See this answer ].
Clearly $y\notin \mathbb{F}_2[x,y]^2$ so $y\notin \mathbb{F}_2(x,y)^2$ (We use this result: Let $R$ be an UFD with fraction field $K$ and $a\in R,n\geq1$, then $a\in R^n$ iff $a\in K^n$. It can be proved easily with the unique factorization.) Hence $f(t)=g(t^2)$ is irreducible of degree 4. It follows that $F(\alpha^{1/2})/F$ is of degree 4 and thus $F(\alpha^{1/2})/F(\alpha)$ is purely inseparable of degree 2.
Let $E=F(\alpha^{1/2})$. Since $E/F(\alpha)$ is purely inseparable and $F(\alpha)/F$ is separable, we must have $F(\alpha)=E^s$ by the uniqueness of separable closure.
(3) Let $K$ be the set of all elements of $E$ that are purely inseparable over $F$. Then $K$ is a sub-extension of $E/F$. Then $[E:K]$ divides $[E:F]=4$, i.e. $[E:K]=1,2$ or $4$.
Case $[E:K]=1$: we have $E=K$ then $F(\alpha)/F$ is both separable and purely inseparable which can only be true if $F(\alpha)=F$, contradiciton.
Case $[E:K]=2$: we have $[K:F]=2$ which must be of the form $F(\sqrt{c})/F$ for some $c\notin F^2$ by the characterization of finite purely inseparable extensions. In particular $K^2\subset F$. Clearly $E=K(\alpha^{1/2})$ as well, let $m(t)$ be the minimal polynomial of $\alpha^{1/2}$ over $K$, then $\deg m=2$ and $m|f$. As $m^2\in F[t]$ (since $K^2\subset F$) is monic and $\deg m^2=4$, we have $m^2=f$, in particular, $m(t)=t^2+y^{1/2}t+z^{1/2}$ so $y^{1/2},z^{1/2}\in K$.
We have $y\notin \mathbb{F}_2[y,z]^2\Rightarrow y\notin \mathbb{F}_2(y,z)^2\Rightarrow [F(y^{1/2}):F]=2$.
We also have $z\notin \mathbb{F}_2[y^{1/2},z]^2\Rightarrow z\notin \mathbb{F}_2(y^{1/2},z)^2 \Rightarrow [F(y^{1/2},z^{1/2}):F(y^{1/2})]=2$.
So $2=[K:F]\geq [F(y^{1/2},z^{1/2}):F]=4$, contradiction.
Hence we must have $[E:K]=4$ and thus $K=F$, so $E/K$ is not separable. $\square$