$PGL(n, F)$ and $PSL(n, F)$ are isomorphic if and only if every element of $F$ has an $n$th root in $F$. ($F$ is a finite field.)
I can show that if $PGL(n, F)=PSL(n, F)$ then $|F|$ have to be even. I have not any idea how to deal with it. Any suggestions?