Suppose first $1<p<\infty$ so that $|u|^p$ is in $C^1(\overline{U})$. Smoothness of $\alpha$ (which can be defined on all of $\Bbb{R}^n$) allows you to justify the use of the divergence theorem, and since $\alpha$ is a fixed smooth vector field, you have uniform bounds on it and all its first derivatives. So,
\begin{align}
\int_{\partial U}|u|^p\,dS&\leq\int_{\partial U}|u|^p\alpha\cdot\nu\,dS\\
&=\int_U[\text{div}(\alpha)|u|^p+p|u|^{p-1}\text{sgn}(u)Du\cdot \alpha]\,dV\\
&\leq C(\|\alpha\|_{\infty},\|D\alpha\|_{\infty})\int_U\left(|u|^p+p|u|^{p-1}|Du|\right)\,dV\\
&\leq C(\|\alpha\|_{\infty},\|D\alpha\|_{\infty})\int_{U}\left[|u|^p+p\left(\frac{p-1}{p}|u|^p+\frac{1}{p}|Du|^p\right)\right]\,dV\tag{$*$}\\
&\leq C(\|\alpha\|_{\infty},\|D\alpha\|_{\infty})\int_U\left(p|u|^p+|Du|^p\right)\,dV,
\end{align}
which completes the proof for $1<p<\infty$. If $p=1$, then you can work through the above derivation with the divergence theorem being applied in a weak sense, or you can (why?) simply take the limit $p\to 1^+$ above… this is why I kept the explicit lack of dependence of the constant $C$ on $p$ (why is this important?). Another way of arguing for $p=1$ is to apply the inequality above for $p=1$ with a ‘regularized’ function $u_{\epsilon}=\sqrt{|u|^2+\epsilon}$, and then taking the limit $\epsilon\to 0^+$. There are several analysis tricks here for dealing with the edge case $p=1$, and you should gain familiarity with as many of them as you can.
For $(*)$, first recall Young’s inequality $ab\leq \frac{a^p}{p}+\frac{b^q}{q}$, where $a,b\geq 0$ and $p,q\in (1,\infty)$ are Holder-conjugate exponents (so $\frac{1}{p}+\frac{1}{q}=1$). Now for any $\xi,\eta\in [0,\infty)$, apply this with $a=\eta$ and $b=\xi^{p-1}$ to get
\begin{align}
\xi^{p-1}\eta\leq \frac{\eta^p}{p}+\frac{(\xi^{p-1})^q}{q}=\frac{\eta^p}{p}+\frac{p-1}{p}\xi^p.
\end{align}
Note that if the Young’s inequality stuff is confusing, then to keep the gist of the argument in mind, focus on $p=2$, then the inequality simply says $ab\leq \frac{a^2+b^2}{2}$ (which is equivalent to the obviously true inequality $(a-b)^2\geq 0$). This means in the above derivation, we simply use $2|u||Du|\leq |u|^2+|Du|^2$.
Having said that, Young’s inequality, and Holder’s inequality are basic inequalities fundamental for real analysis, and as such they should always come to mind as suitable things to try (even if it takes you a while to figure out the right constants/exponents).