Skein is a cryptographic hash function. It was designed for the SHA-3 competition where it became a finalist, but wasn't chosen as SHA-3.
Skein is a family of cryptographic hash functions with internal states of 256, 512 and 1024 bits, each of which is based on the tweakable symmetric block-cipher threefish of the same block size, and a variable output size.
As well as operation as a cryptographic hash, Skein has an extendable argument system that allows it to be used as a mac, a randomized hash, a personalized hash, a pseudo-random-generator, or a stream-cipher.
The Skein hash function was a finalist in the NIST sha-3-competition, but was not selected as sha-3.
See the NIST “SHA-3 Cryptographic Hash Algorithm Competition”) information, or check the related Wikipedia article for more information.